Optical control of membrane tethering and interorganellar communication at nanoscales.

Optical control of membrane tethering and interorganellar communication at nanoscales† †Electronic supplementary information (ESI) available: Experimental procedures, supplemental sequences, figures referred in the text, supplemental movies. See DOI: 10.1039/c7sc01115f Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Calcium Signalling: Mitofusins Promote Interorganellar Crosstalk

Juxtaposition of the endoplasmic reticulum with mitochondria facilitates Ca(2+) fluxes between the organelles. However, the molecular basis of interorganellar tethering remains unknown. A recent report has identified a fundamental role for the dynamin-related mitofusins in the tethering mechanism, thereby ensuring rapid and high fidelity Ca(2+) signalling between the organelles.

Interorganellar Membrane Microdomains: Dynamic Platforms in the Control of Calcium Signaling and Apoptosis

The dynamic interplay among intracellular organelles occurs at specific membrane tethering sites, where two organellar membranes come in close apposition but do not fuse. Such membrane microdomains allow for rapid and efficient interorganelle communication that contributes to the maintenance of cell physiology. Pathological conditions that interfere with the proper composition, number, and phys...

Making heads or tails of phospholipids in mitochondria

Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria...

Comparison of new optical sensor based on triazene ligand immobilized on PVC and triacetylcellulose membranes for Hg (II) Ion

For spectrophotometric analysis of Hg (II) ions, we have used and compared two membranes preparation methods using different polymer; one is poly(vinyl chloride) (PVC) and the other is triacetylcellulose (TAC). In the case of TAC membrane, it was treated with a ligand solution (1.166 × 10-3 mole L-1) in ethylenediamine at the ambient temperature for almost 2-5 min. However, in the case of PVC m...